When you find them together, though, they will most likely make the run. Indeed, both of them have the ability to either make or break a run. Soy milk and Dr Fetus are both items that polarise the Isaac community. Soy Milk / Dr Fetus Soy Milk and Dr Fetus Synergy

All the better if you can find all these items together, just be warned that the ensuing chaos may not be safe for people with epilepsy. To further augment this synergy, look for soy milk, angelic prism, and/or mutant spider. The Tiny Planet item makes your tears orbit Issac in a circular pattern, travelling a fair bit of distance in the process and leading to some immense damage when combined with a Lump of Coal. This makes Tiny Planet the perfect synergising item for a Lump of Coal. The longer your tears travel, the more damage they do. The effect that a Lump of Coal has on tears is simple. A Lump of Coal / Tiny Planet Lump of Coal and Tiny Planet Synergy This is a powerful combination and certainly one of the best synergies in The Binding of Isaac. Now, you can watch your big mass of red tears travel around the room destroying anything in their path. When combined with Ludovico, however, this delay becomes a thing of the past. Monstro’s lung is another divisive item, mainly due to the huge tear delay that comes with it.

One such synergy is that of Monstro’s Lung and Ludovico. The Ludovico technique is a love it or hate it item, but there are some synergies that make it a truly win-running carry. Monstro’s Lung / Ludovico Monstro’s Lung and Ludivco Synergy It is worth noting, however, that this synergy should be avoided with The Lost. It’s also handy for getting into secret and super-secret rooms. Simply walk to an enemy, pull the trigger, and watch them disintegrate into nothingness. Put the two together and you’re about to have crazy amount of fun with near-complete immunity. Kamikaze is an active item that allows you to trigger an explosion at any point. Pyromaniac renders your character immune to any explosive damage and heals your red hearts when taking damage from an explosion. This synergy is only so low in the list because it is incredibly rare to find these items on the same run. Pyromaniac / Kamikaze Pyromaniac and Kamikaze Synergy Habit / Battery / Car Battery / Dull Razorġ0. That being said, here’s our list of the 10 best Binding of Isaac synergies. The efficacy and attractiveness of each synergy are subjective, however, and that’s part of the appeal of the game. Some runs, admittedly, are better than others – most likely because of a game-breaking synergy. Indeed, no two runs on the game are the same, and the different capabilities of each character make it feel different every time you load a new game. Even now, after five-plus years of playing the game consistently, we are discovering new run-winning synergies that make the game so compelling.ĭespite being released in 2011, this roguelike video game (designed by Edmund McMillen) has gained a cult following that seems to be growing exponentially.

One of the reasons why The Binding of Isaac is so addictive is the multitude of synergies available in the game. For many others, too, it is the go-to game that people play when they are undecided on what to select from their back catalogue of games. The Binding of Isaac is a contender for our favorite game ever here at Blog of Games.

Brimstone tiny planet spoon bender